Detalhe da pesquisa
1.
GDF15 promotes weight loss by enhancing energy expenditure in muscle.
Nature
; 619(7968): 143-150, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37380764
2.
Protective effects of 6-ureido/thioureido-2,4,5-trimethylpyridin-3-ols against 4-hydroxynonenal-induced cell death in adult retinal pigment epithelial-19 cells.
Bioorg Med Chem Lett
; 28(2): 107-112, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29208521
3.
Up-regulation of cathepsin S expression by HSP90 and 5-HT7 receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer.
Breast Cancer Res Treat
; 161(1): 29-40, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27796714
4.
Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.
Mol Cancer
; 15(1): 75, 2016 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27871326
5.
5-Hydroxy-7-azaindolin-2-one, a novel hybrid of pyridinol and sunitinib: design, synthesis and cytotoxicity against cancer cells.
Org Biomol Chem
; 14(21): 4829-41, 2016 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27145715
6.
Synthesis and antiangiogenic activity of 6-amido-2,4,5-trimethylpyridin-3-ols.
Bioorg Med Chem Lett
; 24(14): 3131-6, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24894557
7.
Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis.
Diabetes
; 73(1): 51-56, 2024 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37847913
8.
Inhibition of NADPH Oxidase (NOX) 2 Mitigates Colitis in Mice with Impaired Macrophage AMPK Function.
Biomedicines
; 11(5)2023 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37239114
9.
Antitumor effect of 3-(quinolin-2-ylmethylene)-4,6-dimethyl-5-hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis.
Eur J Med Chem
; 251: 115274, 2023 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36921529
10.
Metformin-induced reductions in tumor growth involves modulation of the gut microbiome.
Mol Metab
; 61: 101498, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35452877
11.
Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK.
Inflamm Bowel Dis
; 27(6): 914-926, 2021 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33252129
12.
Inhibition of tumor growth and angiogenesis of tamoxifen-resistant breast cancer cells by ruxolitinib, a selective JAK2 inhibitor.
Oncol Lett
; 17(4): 3981-3989, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30930994
13.
Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis.
Exp Mol Med
; 50(9): 1-14, 2018 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30185799
14.
Antitumor activity of BJ-1207, a 6-amino-2,4,5-trimethylpyridin-3-ol derivative, in human lung cancer.
Chem Biol Interact
; 294: 1-8, 2018 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30125546
15.
Ameliorating effect of TI-1-162, a hydroxyindenone derivative, against TNBS-induced rat colitis is mediated through suppression of RIP/ASK-1/MAPK signaling.
Eur J Pharmacol
; 827: 94-102, 2018 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555502
16.
4-Hydroxynonenal-induced GPR109A (HCA2 receptor) activation elicits bipolar responses, Gαi -mediated anti-inflammatory effects and Gßγ -mediated cell death.
Br J Pharmacol
; 175(13): 2581-2598, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29473951
17.
Dual Inhibition of NOX2 and Receptor Tyrosine Kinase by BJ-1301 Enhances Anticancer Therapy Efficacy via Suppression of Autocrine-Stimulatory Factors in Lung Cancer.
Mol Cancer Ther
; 16(10): 2144-2156, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28536313
18.
Serotonin disturbs colon epithelial tolerance of commensal E. coli by increasing NOX2-derived superoxide.
Free Radic Biol Med
; 106: 196-207, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28216386
19.
BJ-1108, a 6-Amino-2,4,5-Trimethylpyridin-3-ol Analog, Inhibits Serotonin-Induced Angiogenesis and Tumor Growth through PI3K/NOX Pathway.
PLoS One
; 11(1): e0148133, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26824764
20.
Anti-angiogenic activity of macrolactin A and its succinyl derivative is mediated through inhibition of class I PI3K activity and its signaling.
Arch Pharm Res
; 38(2): 249-60, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25547980